The EndoCannabinoid System

Raphael Mechoulam an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel was the first to Identify Δ9-tetrahydrocannabinol, the main active principle of Cannabis, Cannabidiol and Cannabigerol plus various others. He is also credited for the isolation and the identification of the Endogenous Cannabinoids (Endo-Cannabinoids) Anandamide from the brain and 2-arachidonoyl glycerol (2-AG) from peripheral organs along with his students, postdocs and other collaborators. He discovered Δ9-tetrahydrocannabinol in 1964 and continued to study it until 1970. While our bodies make Endo-Cannabinoids, plants make Phyto-Cannabinoids. These still work in the body similar to how 2-AG and Anandamide work, by interacting with CB1 and CB2 receptors in our body. CB1, was first cloned in 1990; and CB2 was cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues. These are the main molecular targets of the (binding molecule), Anandamide, as well as the Phytocannabinoid, THC. The other main Endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with the Phyto-Cannabinoid, CBD. 2-AG and CBD are involved in the regulation of our appetite, immune system functions and pain management. Because of his research we now know why Cannabis works. This has enabled many other researchers to further our knowledge of the nature of many of life's illness's. No chemotherapy can match this nontoxic anti-cancer action." Even in 2012 a pair of scientists from California Pacific Medical Center in San Francisco found THC stops metastasis in many kinds of aggressive cancer.

Anti-tumor effects

Since 1974 studies have shown that cannabis has anti-tumor effects. The results of a 1974 study, reported in an Aug. 18, 1974, Washington Post newspaper feature, were that cannabis's component, THC, "slowed the growth of lung cancers, breast cancers. Even in a virus-induced leukemia in laboratory mice, plus prolonged their lives by as much as 36 percent.

THC and CBN

" In 1975 an article in the Journal of the National cancer institute titled "Antineoplastic activity of cannabinoids." they reported that "Lewis lung Adenocarcinoma growth was retarded by the oral administration of tetrahydrocannabinol (THC) and cannabinol (CBN). Mice treated for 20 consecutive days with THC and CBN had reduced primary tumor size."
In 1998, a research team at Madrid's Complutense University Led by Dr. Manuel Guzman discovered that THC can selectively induce programmed cell death in brain tumor cells without negatively impacting surrounding healthy cells. This process is called Apoptosis or Programmed Cellular Death. They reported in the March 2002 issue of "Nature Medicine" they had destroyed incurable brain cancer tumors in rats by injecting them with THC. And in 2007 even Harvard Researchers found that compounds in cannabis cut the growth of lung cancer. There is also an organization called The SETH Group that showed compounds in cannabis can stop the growth of human glioblastoma multiforma (GBM) brain cancer cells. The SETH Group says "No chemotherapy can match this nontoxic anti-cancer action."

Timothy Tuck
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Wednesday, 19 July 2017 16:19
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The Endocannabinoid System
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